# Chemgenes Corporation, a DNA RNA Biotechnology company

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  - What We Do
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- Oligonucleotide Synthesis Reagents
  - DNA
  - Amidites (P-O-Cyanoethyl) & Supports
  - Amidites (P-O-Methox) & Supports
  - (P-O-Benzyl) Phosphoramidites
  - Amidites (P-O-Ethoxy) & Supports
  - Alpha DNA Amidites
  - Photocleavable (5’-NPPOC) Amidites
  - Reverse DNA Synthesis
  - Non-Cleavable Supports
  - 5’-Levuinyl Protected Amidites
  - Dimer Phosphoramidites
  - H-Phosphonate Monomers
  - RNA
  - Amidites (P-O-Cyanoethyl) & Supports
  - Amidites (P-O-Methoxy) & Supports
  - Reverse RNA Synthesis
  - Unnatural 2’-5’ Linked RNA
  - Antisense
  - 2’-O-Methyl (P-O-Cyanoethyl) & Supports
  - 2’-O-Methyl (P-O-Ethoxy) & Supports
  - 2’-O-Methyl P-Methyl Phosphonamidites
  - 3’-O-Methyl Amidites and Supports
  - Reverse 2’-O-Methyl Amidites and Supports
  - 2’-O-Deoxy Amidites (P-O-Ethoxy) & Supports
  - 2’-O-Deoxy (P-O-Methoxy) Amidites
  - 2’-O-Deoxy (P-O-isoPropoxy) Amidites
  - 2’-O-Deoxy P-Methyl Phosphonamidites
  - 2’-O-Butyne Amidites and Supports
  - 2’-O-Propargyl Amidites and Supports
  - 3’-O-Propargyl Amidites and Supports
- Nucleosides, Protected Nucleosides
  - Unprotected Nucleosides
  - N-protected Nucleosides
  - DMT-protected Nucleosides
- Specialty Oligonuclotides Synthesis
- Triphosphates

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### Base Modifications

1. 2-thio & 4-thio
2. isoC and isoG
3. 4-Triazolyl - Convertible Bases
4. deoxy Inosine & deox uridine
5. alpha DNA Amidites
6. 3’-Amino & 5’ Amino
7. 2’-trifluoroacetamido-propyl
8. Arabanoside
9. 3’-deoxy Adenosine (Cordecypin)
10. 7-deaza Modifications
11. 7-deaza-7-Iodo Modification
12. 5-methyl cytidine & N-Alkylated
13. 2-aminopurine, nebuylarine, etc.
14. Halogenated Bases, ie 5-iodo-dU
15. Abasic and everse Abasic
16. dideoxy
17. 8-oxo

### Ancillary Reagents

1. Acetonitrile, Wash grade
2. Acetonitrile, Amidite Diluent
3. Activator Solutions
4. Deblock Solutions
5. Capping Reagents
6. Oxidation & Sulfurizing Reagents
7. Drying traps (Moisture Traps)

### Attachment Chemistry

1. 5’-Phosphorylation
2. Fluorophore Amidites & Supports
3. Reporters
4. Quenchers
5. Linker & Spacer Amidites & Supports
6. Branching amidites & Supports
7. Cross-Linking Amidites & supports

Oligonucleotied Purification

## Sulfurizing Reagent

### Product Information: ((Dimethylamino-methylidene)amino)-3H-1,2,4-dithiazoline-3-thione (DDTT)3

Available in bulk and formulated solution.
An efficient sulfurizing reagent with quantitative (greater than 99%) P/S conversion in oligonucleotide synthesis as compared to Beaucage reagent and has further advantage of greater stability in the formulated solutions.
A number of 1,2,4-dithiazolines are described in the literature1,2 and demonstrate high sulfurizing efficiency in oligonucleotide synthesis.
Our data has also shown superior sulfurization by DDTT reagent in solution phase. Unlike Beaucage reagent, DDTT did not yield any detectable level of phosphodiester type by-product.
Recommended formulations for the synthesis of posphorothioate containing oligonucleotides and sulfurizing in solution phase.

DDTT Concentration | Solvent formulation v/v | Oxidation time | Comments
0.05 M | Py/ACN - 3:7 Ph/THF - 2:8 | 2.5 min | Formulation used in oligonucleotide synthesis
0.1 M | PY Py/THF - 4:6 | 2 min | Formulation used in oligonucleotide synthesis>
0.05 M | Acetonitrile | 10 min | Formulation used in solution phase reaction>

### Product Information: dG Amidite (iBu)

(DDTT) Catalogue # RN-3155
5’-DMT-2’deoxy Guanosine (N-iBu)
3’-CE Phosphoramidite
Part No.: ANP-5551
MW: 839.90
Formula: C47H54O3P2
Resources:
Technical Details
Release Criteria, Specifications
Sample Certificate of Analysis
Material Safety Datasheet
Certificate of Origin
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